fig5

Figure 5. Upstream signaling events elicited by photodynamic therapy (Ala/light) leading ultimately to inducible nitric oxide synthase (iNOS) transcriptional upregulation. Key effector proteins (Akt, PI3K, p300, p65, Sirt1) are shown along with key inhibitors (His, LY294002, C646) and their targets^[48]