- Prof. Aamir Ahmad
- Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
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Special Issue Introduction
One phenomenon that makes cancer particularly lethal is that of acquired resistance against therapies. It is critical to better understand cancer drug resistance so as to efficiently manage cancer patients in the clinics. Recent research has highlighted an important role of tumor microenvironment in acquired resistance against cancer therapies. Tumor microenvironment comprises of a number of different components, such as, fibroblasts, immune cells, extracellular matrix etc., which co-exist with cancer cells and the mutual interactions and stimulations drive the progression of tumors through mechanisms that are not clearly understood. The microenvironment that surrounds tumor cells is manipulated to support the mechanisms that help evade cytotoxic effects of therapeutic drugs. The interactions and cross-talks between individual components of tumor microenvironment, and the resulting effects on cancer drug resistance, will be the focus of this special issue. We welcome novel research and detailed review articles addressing the progress made in our understanding of the contributions of tumor microenvironment to the problem of cancer drug resistance.
KeywordsCancer Drug Resistance; Tumor Microenvironment; Tumor Cells; Immune Cells; Fibroblasts; Macrophages; Cancer Relapse
Submission Deadline15 Mar 2021