fig1

Figure 1. The mechanistic interconnection of chemoresistance, tumor invasion, and cancer stemness presents in chemoresistant pancreatic cancer. Mechanisms responsible for the respective connections are described in Table 1. NF-κB: Nuclear factor-κB; ZEB1: zinc-finger-enhancer binding protein 1; EVA1: epithelial V-like antigen 1; MAL2: myelin and lymphocyte protein 2; NPs: nucleoside transporters; CD: cluster of differentiation; Oct4: octamer-binding transcription factor 4; NOx: nitrogen oxides; ROS: reactive oxygen species; STAT3: signal transducer and activator of transcription 3; ESA: epithelial-specific antigen; PDAC: pancreatic ductal adenocarcinoma.