fig6

Figure 6. Infiltration of macrophages is likely compromising the growth of SC263-S tumors and the resistance to cetuximab of SC263-R tumors in CB17 Scid mice. Representative images of immunohistochemical staining for Ki67 (proliferation), cleaved caspase-3 (apoptosis), F4/80 (macrophages), and NKp46 (NK cells), shown at 100x. Vehicle: PBS; Cet low: 2.5 mg/kg cetuximab; Cet medium: 10 mg/kg cetuximab. NK: Natural killer; PBS: phosphate-buffered saline; -R: cetuximab-resistant HNSCC cell line; -S: cetuximab-sensitive HNSCC cell line.