fig6
Figure 6. Effects of mevalonic acid, farnesyl pyrophosphate and geranylgeranyl pyrophosphate on simvastatin potentiation of CHR2863 activity. U937/WT, U937/CHR2863R0.2 and U937/CHR2863R5 cells were incubated for 72 h with the indicated concentrations of CHR2863 and non-toxic concentration of simvastatin in the presence of increasing concentrations of (A) mevalonic acid, (B) farnesyl pyrophosphate (FPP) and (C) geranylgeranyl pyrophosphate (GGPP). Results, presented as cell growth relative to control, are the mean ± SD of 4 independent experiments. The dashed line indicates the mean growth inhibition by CHR2863 alone. CHR2863: (6S)-[(R)-2-((S)-Hydroxy-hydroxycarbamoyl-methoxy-methyl)-4-methyl-pentanoylamino]-3,3 dimethyl-butyric acid cyclopentyl ester.
