fig6

From: P-glycoprotein (ABCB1) - weak dipolar interactions provide the key to understanding allocrite recognition, binding, and transport

Figure 6. ABCB1 ATPase activity in NIH-MDR1-G185 cells (filled symbols) and inside-out plasma membrane vesicles (open symbols) induced by three drugs. (A-C) ATPase activity expressed as percent of the basal value in the absence of drugs. (D-F) ATPase activity expressed as protons (i.e., lactic acid) or phosphate released per ABCB1 per second. Calculations are based on the expression level of ABCB1 determined for NIH-MDR1-G185 cells ^[124]. (A and D) Verapamil P-glycoprotein (ABCB1) - weak dipolar interactions provide the key to understanding allocrite recognition, binding, and transport ; (B and E) diltiazem , and (C and F) daunorubicin. Lines are fits to Supplementary Equation 12. Standard deviations are shown (taken from Ref.^[69]). With copyright permission from BBA.