fig4

From: P-glycoprotein (ABCB1) - weak dipolar interactions provide the key to understanding allocrite recognition, binding, and transport

Figure 4. ABCB1 ATPase activity vs. allocrite concentration curves. ATPase activity measured in inside-out plasma membrane vesicles from NIH-MDR1-G185 cells^[25]. Data are fitted to the two-site binding model by Litman et al.^[96]. Tariquidar (diamonds); OC144 093 (circles), cyclosporine A (stars), DDM (squares), verapamil (triangles). Tariquidar, OC144 093, and verapamil inhibit as dimers. DDM^[79] and cyclosporine A (see Ref.^[79], Supplementary Table 3 therein) most likely inhibit as monomers due to their unfavorable q = P-glycoprotein (ABCB1) - weak dipolar interactions provide the key to understanding allocrite recognition, binding, and transport / values (see below).