fig1

Loss of HER2 in breast cancer: biological mechanisms and technical pitfalls

Figure 1. HER2 downregulation, subtype switch, and clonal selection are biological mechanisms potentially responsible for HER2 loss. In parallel, technical pitfalls can cause false-negative results. Figure partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license and adapted from Mathews et al.[13] (http://creativecommons.org/licenses/by/4.0/). HER2: Human epidermal growth factor receptor-2.

Cancer Drug Resistance
ISSN 2578-532X (Online)

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