fig1

Figure 1. Energy metabolism in AML. Glucose is converted to pyruvate by glycolysis. Pyruvate is converted to acetyl-CoA for use in the tricarboxylic acid (TCA) cycle. ATP is produced by oxidative phosphorylation (OXPHOS) in the TCA cycle and electron transport chain (ETC). Fatty acid metabolism supplies acetyl-CoA to the TCA cycle via β-oxidation of fatty acids (FAO). Glutamine metabolism is the process of converting glutamine to glutamic acid. a-KG: Alpha-ketoglutarate; FAS: fatty acid synthase; OAA: oxaloacetic acid; ROS: reactive oxygen species.