fig3

Figure 3. SMI reversed cisplatin resistance in A549/DDP cells. (A) Direct cytotoxic effects of SMI in A549/DDP cells. A549/DDP cells were treated with various concentrations (5, 10, 20, 40, 80, and 160 mg/mL) of SMI for 24 h. (B) Cytotoxic effects of SMI and cisplatin in A549/DDP cells. A549/DDP cells were pre-treated with various concentrations (13, 20, and 30 mg/mL) of SMI (the approximate IC₅, IC₁₀, and IC₂₀, respectively) for 2 h and then exposed to cisplatin (15, 30, 60, 120, and 240 μM) for another 24 h. The cell viability was determined using a Cell Counting Kit. Each data point represents the mean ± SD of the results from four individual measurements. SMI: Shenmai injection.