fig2

Figure 2. Factors causing resistance to anti-cancer drugs in ABCB1- or ABCG2-overexpressing colon cancer cell lines and an ABCB1-overexpressing HeLa cell line. Resistance factors for SN-38, irinotecan, topotecan, mitoxantrone, anthracyclines, 5-fluorouracil, and platinum anticancer drugs are shown relative to the respective parental cell lines. Cell lines are HCT116-SN6 [2004 (COL), ABCG2-overexpressing colon cancer cell^[10] (orange)], S1-IR20 [2021 (COL), ABCG2-overexpressing colon cancer cell^[11] (gray)], S1-B1-20 [2000 (COL), ABCB1-overexpressing colon cancer cell^[12] (yellow)], and Hvr100-6 [2002 (HeLa), ABCB1-overexpressing HeLa cell^[13] (blue)]. Establishments of these resistant sublines are described in Table 1. ND: Not determined.