fig1

Figure 1. Schematic illustration of HGF-mediated functions on malignant plasma cells or accessory cells of the MM microenvironment. Higher levels of HGF have been detected in sera or BM plasma from MM patients than in that from normal controls. HGF, produced in both autocrine and paracrine manners, may stimulate survival and expansion of MM cells, increase angiogenesis and osteoclastogenesis, and reduce osteoblastogenesis. HGF: Hepatocyte growth factor; MM: multiple myeloma; BM: bone marrow.