fig6

Figure 6. Synergy between auranofin and celecoxib against colon cancer in vitro and in vivo through a novel redox-mediated mechanism. CE induces ROS increase, which in turn causes oxidation of proteins (Trxs, HK, and MTCO2). AF inhibits TrxR, and thus keeps Trxs in oxidized form, which cannot reduce/repair the oxidized proteins (HK and MTCO2), leading to inhibition of both glycolysis and mitorespiration, ATP depletion, and cell death. Reproduced and adapted from Han et al.^[56] under the Creative Commons Attribution License 4.0 International (CC BY 4.0). CE: Celecoxib; ROS: reactive oxygen species; HK: hexokinase.