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Figure 5. The effect of the combination of auranofin with celecoxib in mice. Athymic nude mice bearing DLD-1 xenografts were treated with the following drugs via oral injection (P.O.): olive oil (vehicle), AF 10 mg/kg, CE 20 mg/kg, CE 60 mg/kg, AF 10 mg/kg + CE 20 mg/kg (A + C20), and AF 10 mg/kg + CE 60 mg/kg (A + C60). Eight days after inoculation, the tumor size and body weight of mice from each group (six mice per group) were measured two times per week. The three panels show the body weight, tumor volume, and tumor weight during the treatment. Reproduced and adapted from Han et al.^[56] under the Creative Commons Attribution License 4.0 International (CC BY 4.0). AF: Auranofin; CE: celecoxib.