fig2

Figure 2. (A) Cartoon representation of the secondary structures of human thioredoxin-1-thioredoxin reductase 1 (Trx1-TrxR1) complex PDB: 3qfa. (B) The contact patches with direct molecular contacts are highlighted in yellow. (C) The isosurfaces of the electrostatic potential are depicted in blue (positive) and red (negative). The active site cysteinyl residues and interaction surfaces in the immediate contact area in both proteins are encircled in white lines. Reproduced and adapted from Hossain et al.^[47] under the Creative Commons Attribution License 4.0 International (CC BY 4.0).