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Figure 2. Lipid droplet usage in drug-resistant cells. Drug-resistant cells have been shown to increase lipid droplet accumulation (yellow circles) and have a higher percentage co-localized to the mitochondria, where an increase in PLIN4 helps to better utilize lipids for fatty acid beta-oxidation. Lipids can also be used as drug “sinks” for hydrophobic drugs. Figure created with BioRender.