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From: Fusobacterium nucleatum: a new player in regulation of cancer development and therapeutic response
Figure 2. The mechanisms by which Fn initiates and promotes carcinogenesis and enhances disease progression. Fn plays an important role in the whole process of cancer carcinogenesis and progression, supporting the notion that Fn may have a causative role in different states of cancer rather than being a consequence of cancer development. (A,B) Mechanisms of FadA and Fap2 on host cell adherence and invasion. (C-E) Host responses for cancer initiation and promotion including DNA damage, antitumor immune evasion, and pro-inflammatory environment. (F,G) Fn-induced tumor invasion and metastasis for cancer progression. Fn: Fusobacterium nucleaum.
