fig1
Figure 1. Mechanism of actions of sorafenib. Sorafenib inhibits tyrosine kinase receptor (VEGFR, PDGFRβ, Kit and RET) signaling and suppresses the activation of Raf, thus could suppress tumor progression by inhibiting angiogenesis and cell proliferation. Created with BioRender.com. VEGFR: Vascular endothelial growth factor receptor.