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From: ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer

ONECUT2 as a key mediator of androgen receptor-independent cell growth and neuroendocrine differentiation in castration-resistant prostate cancer

Figure 1. Role of ONECUT2 in AR independence and NE differentiation. ADT: Androgen deprivation therapy; NE: neuroendocrine; mCRPC: metastatic castration-resistant prostate cancer; ONECUT2: one cut domain family member 2; REST: RE1-silencing transcription factor; AR: androgen receptor; PEG10: paternally expressed gene 10; Rb1: retinoblastoma gene 1; FOXA1: forkhead box A1; TP53: p53-encoding gene; SMAD3: SMAD family member 3; HIF1α: hypoxia-inducible factor 1 alpha.

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Committee on Publication Ethics

Portico

Committee on Publication Ethics

Portico