fig5

Figure 5. Investigation of the large heterogeneity in tumor macrophages and tumor size with intravital microscopy. (A). Early-stage tumors with clear indication of surrounding tumor associated macrophage (TAM) presence. TAM infiltration is observed in response to 16 individual tumor cells within a single nascent nodule. Scale bars, 1000 mm (top), 100 mm (middle/bottom). (B) Mouse tumor analysis at 2 stages of disease progression revealing facile tumor detection at varying locations and heterogeneous distribution of TAM. Dashed lines outline the lung. Scale bars, 1000 mm. For all, days denote time post inoculation. Figure reproduced with permission from^[34].