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Figure 2. Computed tomography (CT) images using a negative CT contrast agent designed to generate hydrogen in response to acidic pH in the tumor microenvironment of osteosarcoma. (A, C) CT images of osteosarcoma-bearing rats by intratumor and intravenous injection of HMSN@AB@PEG nanoparticles (at various time points). Transverse gray and corresponding pseudo color images were obtained with a dashed line representing the area of osteosarcoma and the region of arrows was the low CT density area of H2 release. The rectangle ROI were used to calculate the variation of CT density between two time points (Pre and 120 min). (B, D) Corresponding intratumor and intravenous 3D reconstruction maps of rat with a dashed line representing the area of osteosarcoma. Figure reproduced with permission from[193].
