fig1

Figure 1. Schematic diagram of PLAD-MLP, a liposome formulation with co-encapsulated Ald, Dox and MLP (prodrug of MMC). A liposome formulation with MLP in the lipid bilayer and ammonium (NH₄)Ald in the water phase is remote loaded with Dox, resulting in a multidrug liposome co-encapsulating two potent cytotoxic agents, and an immunomodulatory aminobisphosphonate (Ald). (NH₄)Ald can be replaced with ammonium sulfate without affecting the remote loading of Dox