fig6
From: Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer
Figure 6. Schematic representation of the SLNs structure, representing the solid lipid matrix, surfactant, and co-surfactant[83] (A); Classification of three types of classical SLNs including drug-enriched shell, drug-enriched core, and solid solution[85] (B); Images of spheroids formation in different period of time with respective size (μm). MCF-7/ADR (a), NCI/ADR (b). Images are representative of triplicate samples[93](C); Development of fucose decorated methotrexate loaded SLNs (D). The proposed mechanism of action is methotrexate via ligand-receptor mediated endocytosis and internalization[96]
