fig4

EGFR signaling promotes resistance to CHK1 inhibitor prexasertib in triple negative breast cancer

Figure 4. Erlotinib co-exposure with prexasertib synergistically enhanced cell killing. Viability of 3D cultures of MDA-231 (A) and MDA-468 (B) after exposure to prexasertib, erlotinib, and combinations of erlotinib and prexasertib; the combination index (CI) showed synergistic interaction (CI < 1) of erlotinib and prexasertib in both MDA-231 and MDA-468 (C)

Cancer Drug Resistance
ISSN 2578-532X (Online)

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Portico

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