fig2

Figure 2. Conversion of 11-oxygenated androgens to 11-keto-Testosterone and 11-keto-DHT. The pathway from adrenal 11β-hydroxy-⁴AD and 11-keto-⁴AD to 11-keto-testosterone and 11-Keto-DHT, respectively is shown. The enzymes implicated in this conversion in the prostate are shown. All enzymes are listed in italics by their gene names. AKR1C3, type 5 17β-hydroxysteroid dehydrogenase; HSD11B2, type 2 11β-hydroxysteroid dehydrogenase; and SRD5A1/2, type 1 and type 2 steroid 5α-reductase