fig7

Figure 7. Analysis of survival rates of ABCB1 mutations in the Cancer Genome Atlas (TCGA). The analysis was compared with cancer cases with gene mutations in TP53 (as control) and in four other ABC transporter genes (i.e., ABCA1, ABCC1, CFTR and ABCG2). The analysis was implemented on June 26, 2020, which was based on the Data Release 24.0 on May 7, 2020 at the National Cancer Institute GDC Data Portal (https://portal.gdc.cancer.gov). At the time of the analysis, the TCGA had a total of 11,315 cancer cases, 22,872 documented genes and 3,142,246 mutations. A-F: the cancer cases for each gene used in this analysis are described as follows: TP53 mutated (n = 4,334) and not mutated (n = 6,981), ABCB1 mutated (n = 1003) and not mutated (n = 10,312), ABCA1 mutated (n = 846) and not mutated (n = 10,469), ABCC1 mutated (n = 788) and not mutated (n = 10,527), CFTR mutated (n = 1,209) and not mutated (n = 10,106), and ABCG2 mutated (n = 682) and not mutated (n = 10,633); G: pharmaceutical therapy in mutated (n = 479) and not mutated (n = 4,198) ABCB1 cases; H: no therapy in mutated (n = 711) and not mutated (n = 6,728) ABCB1 cases. Log-rank test P-values are indicated in each plot. The P-value for TP53 in Figure 7A shows 0.00E+0 because the P-value is extremely low and goes beyond the precision inherent in the code