fig7

Figure 7. Mechanism of adenosine generation and its effects blocking T and NK cells. The generation of adenosine can be inhibited by either blocking the CD73 or CD38 exonucleases. Trials have been started (A); how tertiary lymph follicles can be formed. On the left side the natural mechanisms are shown. On top right the possible therapeutic intervention is shown (B); how to block the “no-eat-me” signal: a therapy using a blocking antibody for CD47 in combination with antiPDL1 will result in antigen processing by a macrophage, presentation of the antigen to cytotoxic T cells; as the PDL1 on expressing tumor cell is also blocked by an antiPDL1 antibody, the T lymphocyte can act and finally kill the tumor cell (C). PDL1: programmed death ligand 1