fig2

Figure 2. Targeting either the transforming growth factor β1 pathway or ELTD1 in pre-clinical studies for glioblastoma multiforme (GBM). OKlahoma Nitrone 007 (OKN-007) is able to significantly increase animal survival (A) or decrease tumor volumes (B) following combined OKN-007 and TMZ treatments in an orthotopic G55 GBM xenograft model. Examples of MR images from untreated (UT) (C), OKN-007- (OKN) (D), TMZ- (E), or combined (OKN-007 + TMZ) (F) treatments; a monoclonal antibody (mAb) against ELTD1 significantly increased animal survival (G) and decreased tumor volumes (H) in an orthotopic G55 GBM xenograft model; (I) Notch 1 levels were significantly decreased with a mAb against ELTD1 in a G55 GBM model. This figure was obtained from modified data with the permission of Dr. Towner, as reported in Towner et al.^[40] and Zalles et al.^[74]