fig4

Figure 4. Increased proliferation rate, invasion rate, MMP-9 activity, and S100A4 expression in photostressed U87 cells: inducible nitric oxide (NO) synthase/NO-dependency. A: 1400W-inhibited proliferation of surviving cells from 24-48 after aminolevulinic acid (ALA)/light treatment. Also shown: insignificant effect of 1400W on ALA-only control; B: 1400W-inhibited invasion of surviving cells 24 h after ALA/light ytratment; **P < 0.01 vs. ALA/light; C: 1400W- and L-NAME-inhibitable MMP-9 activation. Extracellular enzyme after ALA/light was concentrated and analyzed for activity by in-gel zymography. *P < 0.01 vs. ALA/hν; D: 1400W-inhibitable S100A4 upregulation after an ALA/light challenge^[42]