fig5

DNA direct reversal repair and alkylating agent drug resistance

Figure 5. Repair of 1-methyladenine and 3-methylcyotsine. The reaction converts α-ketoglutarate to succinate with CO2 release and requires oxygen and Fe(II). There is also a release of formaldehyde to regenerate the normal base. 1-meA: 1-methyladenine; 3-meC: 3-methylcytosine.

Cancer Drug Resistance
ISSN 2578-532X (Online)

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