fig4

Figure 4. ABCA1 mRNA expression is increased in ovarian cancer cells with acquired carboplatin resistance. (A) ABCA1; (B) ABCB1; (C) ABCB3; (D) ABCC2; and (E) ABCG2 expression in parental (OVCAR-5 and CaOV3) and carboplatin resistant ovarian cancer cell lines (OVCAR-5 CBPR and CaOV3 CBPR). For the cell line, the columns represent the mean fold changes ± SEM from 12-20 RNA samples from 4-6 independent experiments. *P < 0.05, unpaired t test. Data for the primary HGSOC cells from patients with chemosensitive at diagnosis (n = 9) or acquired chemoresistance following relapse (n = 6) are expressed as the median fold change from 3-6 RNA samples from two independent experiments. *P = 0.026, Mann-Whitney U test. ABCB1 was not detectable in OVCAR-5 cells.