fig6

Figure 6. Disruption of HER2 signaling by destabilizing cholesterol content and lipid raft formation. Statins and anti-diabetic agent, metformin, can inhibit HMGCR and disrupt cholesterol signaling. Lapatinib directly targets HER2. Metformin can also target key enzymes critical to cholesterol synthesis pathways, which include HMGCoA, HMGCR, MVD, SQLE, LSS, and DHCR24 (red). Images were created using Biorender.com. EGFR: epidermal growth factor receptor; HER2: human epidermal growth factor receptor 2; HMGCoA: 3-hydroxy, 3-methylglutaryl-CoA; HMGCR: HMG-CoA reductase; MVD: mevalonate diphosphate decarboxylase; SQLE: squalene expoxidase; LSS: lanosterol synthase; DHCR24: 24-dehydrocholesterol reductase