fig6

Figure 6. Suppression of xenograft growth by Fenoldopam and fluorescent imaging of dopamine receptor-1 (D1R)-expressing tumors. Treatment with Fenoldopam (Fen), delivered by Alzet osmotic mini-pumps, markedly reduced growth of SUM159-derived xenografts in athymic nude mice (A); Control (Con), no pumps; Fen, mice had the pumps for three weeks; Fen: 7D, mice had the pumps removed after seven days. n = 6-8 mice/treatment. Fluorescence imaging of D1R-expressing xenografts (B). Mice with MDA-MB-231-derived tumors were i.v. injected with human anti-D1R antibody conjugated to Alexa-Fluor 647. In vivo fluorescence imaging after 24 h shows intense fluorescence of the primary tumor and metastases. Arrows in insets show H&E staining of primary tumor and metastases in axillary lymph nodes. Redrawn and modified^[2]