fig1

Figure 1. Schematic representation of miRs involved in neuroblastoma (NB) genesis, tumor progression, and therapy resistance. While cellular function- and NB process-specific miR modulation were realized, it was also clear that the functional roles of miRs (e.g., miR-9, miR-92) are conserved across the process, at least in the NB setting. In-depth analysis and crisscross comparisons of the documented functional roles of miRs across NB biological processes showed NB process (genesis, progression, therapy resistance) - specific miR(s) regulation/deregulation; within a process, function-specific miR(s) modulation; activation of function-specific miRs is complemented with compromised incompatible miR(s) (e.g., oncomiR activation with concomitant decrease of tumor suppressor miR or vice versa) and; the involvement of select miRs across the function within a process and also across the processes of NB evolution