fig2

Figure 2. MEK inhibition dynamically reprograms the kinome and RTK signalling network. A: Inhibition of MEK disrupts a repressing transcriptional program exerted by the transcriptional factor c-Myc on the RTKs, which leads to induced expression and activation of an array of RTKs; B: MEK inhibition triggers a dynamic genome-wide enhancer formation with pronounced BRD4 density co-occupied with typical enhancer marks, causing increased expression and subsequent activation of RTKs, including PDGFRB, FGFR2, and DDR1