fig6

Figure 6. Positive and negative feedback loops in NRF2 signalling. A: The positive feedback regulatory loop of NRF2 and other proteins and signalling pathways that upregulate NRF2 and functions. Showing, in part, the mutual regulatory loop between NRF2 and HER family receptors; B: The negative feedback regulatory loop of NRF2 and other proteins and signalling pathways that repress NRF2 and functions. NRF2: nuclear factor E2-related factor 2