fig4

Figure 4. Cooperativity of NRF2 and HER family receptors in cellular proliferation and cancer. The NRF2-ARE pathway cross-talks with the HER family receptor and other signalling pathways. This provides rationale and justification for the use and design of anticancer drugs and/or molecules that target HER family receptors and/or target NRF2 to enhance the action and effectiveness of HER targeting anticancer therapies and delay or overcome resistance. NRF2: nuclear factor E2-related factor 2