REFERENCES
1. Ledermann J, Harter P, Gourley C, Friedlander M, Vergote I, et al. Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. N Engl J Med 2012;366:1382-92.
2. Ledermann J, Harter P, Gourley C, Friedlander M, Vergote I, et al. Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. Lancet Oncol 2014;15:852-61.
3. Mirza MR, Monk BJ, Herrstedt J, Oza AM, Mahner S, et al. Niraparib maintenance therapy in platinum-sensitive, recurrent ovarian cancer. N Engl J Med 2016;375:2154-64.
4. Ledermann J, Oza AM, Lorusso D, Aghajanian C, Oaknin A, et al. LBA40_PRARIEL3: a phase 3, randomised, double-blind study of rucaparib vs placebo following response to platinum-based chemotherapy for recurrent ovarian carcinoma (OC). Ann Oncol 2017;28.
5. Pujade-Lauraine E, Ledermann JA, Selle F, Gebski V, Penson RT, et al. Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Oncol 2017;18:1274-84.
6. Kaufman B, Shapira-Frommer R, Schmutzler RK, Audeh MW, Friedlander M, et al. Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. J Clin Oncol 2015;33:244-50.
7. Robson M, Im SA, Senkus E, Xu B, Domchek SM, et al. Olaparib for metastatic breast cancer in patients with a germline BRCA mutation. N Engl J Med 2017;377:523-33.
8. Moore K, Colombo N, Scambia G, Kim BG, Oaknin A, et al. Maintenance Olaparib in patients with newly diagnosed advanced ovarian cancer. N Engl J Med 2018;379:2495-505.
9. Domchek SM, Aghajanian C, Shapira-Frommer R, Schmutzler RK, Audeh MW, et al. Efficacy and safety of olaparib monotherapy in germline BRCA1/2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy. Gynecol Oncol 2016;140:199-203.
10. Oza AM, Tinker AV, Oaknin A, Shapira-Frommer R, McNeish IA, et al. Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2. Gynecol Oncol 2017;147:267-75.
11. Coleman RL, Oza AM, Lorusso D, Aghajanian C, Oaknin A, et al. Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2017;390:1949-61.
12. Litton JK, Rugo HS, Ettl J, Hurvitz SA, Gonçalves A, et al. Talazoparib in patients with advanced breast cancer and a germline BRCA mutation. N Engl J Med 2018;379:753-63.
13. Food and Drug Administration. Veliparib receives orphan drug designation for treatment of advanced squamous non-small cell lung cancer. FDA Orphan Drug Designations and Approvals 2016.
14. Murai J, Huang SY, Das BB, Renaud A, Zhang Y, et al. Trapping of PARP1 and PARP2 by clinical PARP inhibitors. Cancer Res 2012;72:5588-99.
15. Friedlander M, Meniawy T, Markman B, Mileshkin L, Harnett P, et al. Pamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-escalation stage of a multicentre, open-label, phase 1a/b trial. Lancet Oncol 2019; doi: 10.1016/s1470-2045(19)30396-1.
16. Ciardiello F, Bang YJ, Bendell JC, Cervantes A, Brachmann RK, et al. A phase III, double-blind, randomized study of pamiparib versus placebo as maintenance therapy in patients with inoperable, locally advanced, or metastatic gastric cancer (GC) that responded to platinum-based first-line chemotherapy. J Clin Oncol 2019;37:TPS173.
17. Chowdhury S, Mateo J, Gross M, Armstrong AJ, Cruz-Correa M, et al. Pamiparib, an investigational PARP inhibitor, in patients with metastatic castration-resistant prostate cancer (mCRPC) and a circulating tumor cell (CTC) homologous recombination deficiency (HRD) phenotype or BRCA defects: a trial in progress. J Clin Oncol 2019;37:TPS5086.
18. Shen Y, Rehman FL, Feng Y, Boshuizen J, Bajrami I, et al. BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency. Clin Cancer Res 2013;19:5003-15.
19. Berek JS, Matulonis UA, Peen U, Ghatage P, Mahner S, et al. Safety and dose modification for patients receiving niraparib. Ann Oncol 2018;29:1784-92.
20. Golan T, Hammel P, Reni M, Van Cutsem E, Macarulla T, et al. Maintenance Olaparib for germline BRCA-mutated metastatic pancreatic cancer. N Engl J Med 2019;381:317-27.
21. Mateo J, Carreira S, Sandhu S, Miranda S, Mossop H, et al. DNA-repair defects and Olaparib in metastatic prostate cancer. N Engl J Med 2015;373:1697-708.
22. Barkauskaite E, Jankevicius G, Ahel I. Structures and mechanisms of enzymes employed in the synthesis and degradation of PARP-dependent protein ADP-ribosylation. Mol Cell 2015;58:935-46.
23. Weaver AN, Yang ES. Beyond DNA repair: additional functions of PARP-1 in Cancer. Front Oncol 2013;3:290.
24. McCann KE. Poly-ADP-ribosyl-polymerase inhibitor resistance mechanisms and their therapeutic implications. Curr Opin Obstet Gynecol 2019;31:12-7.
25. Haynes B, Murai J, Lee JM. Restored replication fork stabilization, a mechanism of PARP inhibitor resistance, can be overcome by cell cycle checkpoint inhibition. Cancer Treat Rev 2018;71:1-7.
26. Gogola E, Duarte AA, de Ruiter JR, Wiegant WW, Schmid JA, et al. Selective loss of PARG restores parylation and counteracts PARP inhibitor-mediated synthetic lethality. Cancer Cell 2018;33:1078-93.e12.
27. D’Andrea AD. Mechanisms of PARP inhibitor sensitivity and resistance. DNA Repair (Amst) 2018;71:172-6.
28. Jiang X, Li X, Li W, Bai H, Zhang Z. PARP inhibitors in ovarian cancer: sensitivity prediction and resistance mechanisms. J Cell Mol Med 2019;23:2303-13.
29. Patel AG, Sarkaria JN, Kaufmann SH. Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. Proc Natl Acad Sci U S A 2011;108:3406-11.
30. Thomas A, Murai J, Pommier Y. The evolving landscape of predictive biomarkers of response to PARP inhibitors. J Clin Invest 2018;128:1727-30.
31. Hopkins TA, Ainsworth WB, Ellis PA, Donawho CK, DiGiammarino EL, et al. PARP1 trapping by PARP inhibitors drives cytotoxicity in both cancer cells and healthy bone marrow. Mol Cancer Res 2019;17:409-19.
32. Gelmon KA, Tischkowitz M, Mackay H, Swenerton K, Robidoux A, et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol 2011;12:852-61.
33. Fong PC, Yap TA, Boss DS, Carden CP, Mergui-Roelvink M, et al. Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. J Clin Oncol 2010;28:2512-9.
34. Sandhu SK, Schelman WR, Wilding G, Moreno V, Baird RD, et al. The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial. Lancet Oncol 2013;14:882-92.
35. Norquist B, Wurz KA, Pennil CC, Garcia R, Gross J, et al. Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. J Clin Oncol 2011;29:3008-15.
36. Lheureux S, Bruce JP, Burnier JV, Karakasis K, Shaw PA, et al. Somatic BRCA1/2 recovery as a resistance mechanism after exceptional response to poly (ADP-ribose) polymerase inhibition. J Clin Oncol 2017;35:1240-9.
37. Ter Brugge P, Kristel P, van der Burg E, Boon U, de Maaker M, et al. Mechanisms of therapy resistance in patient-derived xenograft models of BRCA1-deficient breast cancer. J Natl Cancer Inst 2016;108.
38. Bouwman P, Jonkers J. Molecular pathways: how can BRCA-mutated tumors become resistant to PARP inhibitors? Clin Cancer Res 2014;20:540-7.
39. Gupta R, Somyajit K, Narita T, Maskey E, Stanlie A, et al. DNA repair network analysis reveals shieldin as a key regulator of NHEJ and PARP inhibitor sensitivity. Cell 2018;173:972-88.e23.
40. Noordermeer SM, Adam S, Setiaputra D, Barazas M, Pettitt SJ, et al. The shieldin complex mediates 53BP1-dependent DNA repair. Nature 2018;560:117-21.
42. Meghani K, Fuchs W, Detappe A, Drane P, Gogola E, et al. Multifaceted impact of microRNA 493-5p on genome-stabilizing pathways induces platinum and PARP inhibitor resistance in BRCA2-mutated carcinomas. Cell Rep 2018;23:100-11.
43. Cruz C, Castroviejo-Bermejo M, Gutierrez-Enriquez S, Llop-Guevara A, Ibrahim YH, et al. RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer. Ann Oncol 2018;29:1203-10.
44. Kondrashova O, Nguyen M, Shield-Artin K, Tinker AV, Teng NNH, et al. Secondary somatic mutations restoring RAD51C and RAD51D associated with acquired resistance to the PARP inhibitor rucaparib in high-grade ovarian carcinoma. Cancer Discov 2017;7:984-98.
45. Peng G, Chun-Jen Lin C, Mo W, Dai H, Park YY, et al. Genome-wide transcriptome profiling of homologous recombination DNA repair. Nat Commun 2014;5:3361.
46. Esposito MT, Zhao L, Fung TK, Rane JK, Wilson A, et al. Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors. Nat Med 2015;21:1481-90.
47. Murai J, Feng Y, Yu GK, Ru Y, Tang SW, et al. Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition. Oncotarget 2016;7:76534-50.
48. Lok BH, Gardner EE, Schneeberger VE, Ni A, Desmeules P, et al. PARP inhibitor activity correlates with SLFN11 expression and demonstrates synergy with temozolomide in small cell lung cancer. Clin Cancer Res 2017;23:523-35.
49. Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, et al. A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. J Clin Invest 2018;128:2116-26.
50. Pettitt SJ, Krastev DB, Brandsma I, Drean A, Song F, et al. Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. Nature communications 2018;9:1849.
51. Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, et al. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med 2016;22:194-201.
52. Gilabert M, Launay S, Ginestier C, Bertucci F, Audebert S, et al. Poly(ADP-ribose) polymerase 1 (PARP1) overexpression in human breast cancer stem cells and resistance to olaparib. PLoS One 2014;9:e104302.
53. Hjortkjær M, Waldstrøm M, Jakobsen A, Kanstrup H, Søgaard-Andersen E, et al. The prognostic value of BRCA1 and PARP expression in epithelial ovarian carcinoma: immunohistochemical detection. Int J Gynecol Pathol 2017;36:180-9.
54. Choi YE, Meghani K, Brault ME, Leclerc L, He YJ, et al. Platinum and PARP inhibitor resistance due to overexpression of microRNA-622 in BRCA1-mutant ovarian cancer. Cell Rep 2016;14:429-39.
55. Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, et al. Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature 2016;535:382-7.
56. Rondinelli B, Gogola E, Yucel H, Duarte AA, van de Ven M, et al. EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation. Nat Cell Biol 2017;19:1371-8.
57. Durmus S, Sparidans RW, van Esch A, Wagenaar E, Beijnen JH, et al. Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) restrict oral availability and brain accumulation of the PARP inhibitor rucaparib (AG-014699). Pharm Res 2015;32:37-46.
58. Oplustilova L, Wolanin K, Mistrik M, Korinkova G, Simkova D, et al. Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment. Cell Cycle 2012;11:3837-50.
59. Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AO, et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci U S A 2008;105:17079-84.
60. Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, et al. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov 2013;3:68-81.
61. Montoni A, Robu M, Pouliot E, Shah GM. Resistance to PARP-Inhibitors in cancer therapy. Front Pharmacol 2013;4:18.
62. Morgillo F, Della Corte CM, Fasano M, Ciardiello F. Mechanisms of resistance to EGFR-targeted drugs: lung cancer. ESMO Open 2016;1:e000060.
63. Christie EL, Fereday S, Doig K, Pattnaik S, Dawson SJ, et al. Reversion of BRCA1/2 germline mutations detected in circulating tumor DNA from patients with high-grade serous ovarian cancer. J Clin Oncol 2017;35:1274-80.
64. Swisher EM, Lin KK, Oza AM, Scott CL, Giordano H, et al. Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial. Lancet Oncol 2017;18:75-87.
65. Marijon H, Lee DH, Ding L, Sun H, Gery S, et al. Co-targeting poly(ADP-ribose) polymerase (PARP) and histone deacetylase (HDAC) in triple-negative breast cancer: higher synergism in BRCA mutated cells. Biomed Pharmacother 2018;99:543-51.
66. Bitler BG, Watson ZL, Wheeler LJ, Behbakht K. PARP inhibitors: clinical utility and possibilities of overcoming resistance. Gynecol Oncol 2017;147:695-704.
67. Ivy SP, Liu JF, Lee JM, Matulonis UA, Kohn EC. Cediranib, a pan-VEGFR inhibitor, and olaparib, a PARP inhibitor, in combination therapy for high grade serous ovarian cancer. Expert Opin Investig Drugs 2016;25:597-611.
