fig1

Figure 1. A: Depicts a poorly vascularized tumor region showing gradients of oxygen, nutrients and waste; B: shows an overlay of a large tumorosphere of a patient which has transformed from NSCLC under Osimertinib treatment to SCLC. The corresponding gradients are shown for the tumorosphere. NSCLC: non-small-cell lung cancer; SCLC: small-cell lung cancer