fig1

Figure 1. Mechanisms of acquired resistance to FGFR inhibition. Mechanisms of acquired resistance to FGFR inhibition can occur through activation of alternate receptor tyrosine kinases and acquired gatekeeper mutations (A), epithelial to mesenchymal transition (B) or activation of intracellular signaling pathways (C). FGFR: fibroblast growth factor receptor; FGFRi: fibroblast growth factor receptor inhibitor; RTK: receptor tyrosine kinase; MAPK: mitogen activation protein kinase; JAK/STAT: Janus kinase/signal transducers and activators of transcription; GSK3β: glycogen synthase kinase 3 beta