fig2

Figure 2. Non-angiogenic tumours are a cause for resistance to anti angiogenic treatment. A: Schematic representation of normal liver; B: a non-angiogenic liver metastases in which the liver architecture is preserved, the metastatic cells (beige) take the place of the hepatocytes exploiting the liver sinusoidal vascular system; C: an angiogenic metastases (green) grows by destroying the liver tissue, new vessels (in red) are sprouting providing the blood flow; D: HT29 Wild Type colorectal cancer cells produces metastases when injected into the mouse liver and the majority of them are non-angiogenic (blue). If HT29 cells with silenced ARP2/3 complex are injected; E: the metastatic growth will be predominantly angiogenic (green). When treatment with an anti VEGF antibody is performed, the angiogenic metastases of wild type tumours regresses, but the non-angiogenic lesions progresses; F: However, in tumours made up by HT29 cells with silenced ARP2/3 complexes the angiogenic metastases respond; G: Because of the silencing of the ARP2/3 complexes, the non-angiogenic metastases do not develop further. (Based on^[32])