fig5
From: Drug resistance mechanisms of cancer stem-like cells and their therapeutic potential as drug targets
Figure 5. Semaphorin/MICAL3 signaling induces symmetric division of CSCs. By semaphorin binding to neuropilin 1 (NP1) receptor, MICAL3/collapsin response mediator protein 2 (CRMP2)/Numb axis is activated, leading to symmetric division and expansion of BCSCs. NP1: neuropilin 1; CRMP2: collapsin response mediator protein 2. CSCs: cancer stem-like cells
