fig4

Figure 4. Intrinsic differences in the mode of division of SSC and CSC allow for the safe elimination of CSC via symmetric differentiative divisions. A: Asymmetric division is preferred in normal somatic stem cells (SSCs). Both symmetric and asymmetric divisions occur in cancer stem cells (CSC), thereby leading to an increase in the CSC population; B: CBP/catenin antagonists (e.g., ICG- 001) force symmetric differentiative divisions in CSC thereby driving the CSC population out of their niche. CBP/catenin antagonists maintain SSC asymmetric divisions thereby never depleting the niche