fig2
From: Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators
Figure 2. The inward-facing exporter binds substrate (D, drug) from the cytoplasm or the inner leaflet of the bilayer. After binding two molecules of MgATP, the nucleotide-binding domains (NBDs) dimerize and switch the transmembrane domain (TMDs) from the inward- to the outward-facing conformation, followed by the release of the drug to the extracellular environment. ATP hydrolysis, ADP/Pi release and NBD dissociation reset the transporter to the inward-facing conformation. The figure is quoted with permission from Wilkens[47].
