fig4
Figure 4. Conserved coupling interface between ICD and NBD (A) Structural alignment of NBD1s from the structures of mP-gp with different DCOM values. The alignment of NBD1 also brings ICD1 to superposition, whereas the rest of P-gp is not aligned. (B) Here, structural alignment is carried out for NBD2s from structures of mP-gp with different DCOM values. The alignment of NBD2 also brings ICD2 to superposition, but not the rest of P-gp
