fig2
From: Use of MRI, metabolomic, and genomic biomarkers to identify mechanisms of chemoresistance in glioma
Figure 2. Dichloroacetate (DCA) improves the responsiveness of resistant glioma cells to BCNU. Treatment of BCNU-sensitive (9L-S) and BCNU-resistant (9L-R) glioma cells with (A) 75 µM or (B) 100 µM BCNU resulted in significant death of 9L-S, but not 9L-R cells. Addition of 25 mM DCA potentiated the action of BCNU in 9L-R cells at both concentrations of BCNU. Bars (mean ± SD, n = 6) with different letters (a vs. b) are significantly different from each other at P ≤ 0.05. DCA: dichloroacetate
