fig2

Figure 2. Schematic view of the 3D structure of the non-covalent hTopIB-DNA complex in two different orientations. A: Different domains and DNA forming the complex; B: core subdomains I and II forming the “Cap” region and the residues belonging to core subdomain III and the C-terminal domain forming the “Cat” region. At the top are two loops or lips and opposite to the lips are the chains of the “hinge” residues. This molecular picture was produced with UCSF Chimera program^[35]