fig2

Figure 2. Regulation of TYMS expression by its antisense mRNA, enolase superfamily member 1 (ENOSF1). ENOSF1 gene, encoding a mitochondrial enzyme also known as reverse TS (rTS), is located adjacent to TYMS and a regulatory interaction between the two genes/proteins has been suggested. High expression level of ENOSF1 has been found to suppress the TS expression level by either inducing the production of an antisense RNA targeting TYMS mRNA or by inducing the expression of a protein (i.e., rTS-β) modulating the TS protein level at the post-transcriptional phase. ENOSF1 polymorphisms (i.e., rs2612091) could perturb this TYMS mRNA-antisense mRNA autoregulatory complex