fig1

Figure 1. Chemical structures of cis- and carboplatin (A). Action of platinium. Cisplatin [Cis-diamminedichloroplatinum (II)] forms intracellular electrophilic water complexes based on the commonly predominant lower chloride concentrations. Due to its high affinity to the bases guanine and adenine, it forms chelates and inhibits DNA expression. Crosslinks of the DNA single and double strands are formed by platination with a disorder of template function and cell division. Carboplatin [Cis-Diamin (1,1cyclobutandicarboxylo)-platinium] has an equivalent mechanism of action. Chelation and cross-linking of the single and double-stranded DNA inhibit DNA synthesis and transcription triggering apoptosis (B)