fig2

Figure 2. Mechanism of anticancer activity of anti-EGFR mAbs. Cetuximab and panitumumab bind to EGF receptors, thus preventing further signalling transduction via PI3K/mTOR and RAS/ERK pathways. Inactivation of growth signalling pathways prevents cell proliferation and survival. EGFR: epidermal growth factor receptor; mAbs: monoclonal antibodies